Charlie Gard's death is the main news for the Daily Mail, the Daily Mirror and the Sun.
The Mirror says his tragic story touched a nation.
It was all the more poignant because there was never going to be a happy ending, the paper adds.
Its headline quotes the statement issued by his parents: "Our beautiful little boy has gone."
The Sun has the headline: "RIP our hero".
The Mail says his death ends months of turmoil and court drama in which Chris Gard and Connie Yates fought for treatment they hoped would save him.
"Rest in peace, Charlie," is the headline.
The Daily Telegraph and the Daily Express lead on the chancellor's suggestion that there could be a transition period of up to three years after the UK leaves the EU in 2019.
The Telegraph says Philip Hammond's comments have prompted alarm among Leave campaigners and some MPs.
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It says they fear that if Britain is still in a state of flux at the next election - in 2022 at the latest - Remain supporters will seize the chance to water down Brexit and even try to reverse the process.
According to the Express, many Remainers hope a slow Brexit will mean that Leave supporters will lose heart, and a possible economic downturn could be used as an excuse to hold another referendum.
For its main story, the Guardian says the Mayor of London, Sadiq Khan, has set out the possibility of the UK remaining within the EU, arguing that Brexit could be legitimately stopped if Labour included the pledge in an election manifesto or committed to a second referendum.
It says his intervention is likely to fuel Labour divisions on Brexit, as the leadership is adamant that the party should respect last year's result but some MPs believe it should fight for a second referendum.
The i newspaper reports that campaigners are calling on the government to come clean over the costs of the HS2 rail project, after details of the budgets and timescales were obscured or redacted in official documents.
It says the Stop HS2 group has accused Transport Secretary Chris Grayling of failing to back up his own claims that the project will be on time and on budget.
The Department for Transport tells the paper that the redactions contain commercially sensitive information.
The DfT later issued a statement in response to the story, saying it was "keeping a tough grip on costs and the project is on time and on budget at £55.7bn".
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